I-Bioreactor Sparger

Umbono Ojwayelekile We-Sparge Tube Design

Ama-bioreactors amancane angasabalalisa kahle umoya-mpilo futhi asuse isikhutha ngaphandle kwama-nebulizer. Kodwa-ke, lezi zinyathelo azisebenzi kuma-bioreactors amakhulu, njengoba indawo ephansi engaphezulu nesilinganiso sevolumu iholela ekuqongeleleni kwe-carbon dioxide futhi ivimbele ukungena komoyampilo. Ngakho-ke, ama-nebulizers ayadingeka ukuze kwethulwe umoya-mpilo kanye nokususwa kwe-carbon dioxide.

Amasistimu anama-nebulizer amancane namakhulu avame ukuba usizo ngoba angakwazi ukuhlangabezana nezidingo zezinqubo ezahlukene. Isibonelo, ama-nebulizer amakhulu akhiqiza amabhamuza amakhulu asusa ngempumelelo i-CO 2 esixazululweni, kodwa amabhamuza amakhulu adinga ukuyaluza okunamandla ukuze awaphule futhi akhulule umoya-mpilo.

Nakuba lokhu kungase kusebenze kahle kumaseli abekezelela ukubanda, ukunyakazisa kungalimaza amangqamuzana ezilwane ezincelisayo athambile. Kulezi zimo, i-macro-distributor enamandla aphansi ingasetshenziswa kuqala ukususa i-CO 2 bese kuba isisabalalisi esincane ochungechungeni ukukhiqiza amabhamuza amancane aletha umoya-mpilo ngempumelelo.

I-Sintered Porous Metal Sparger Yenza

I-Interfacial Area Iyanda Kodwa Ubukhulu Bamabhamuza Buyancipha

Inselele: Izimpawu Zebhamuza Zinquma Izilinganiso Zokuthutha ze-O2 kanye ne-CO 2 Vapor Extraction

Ukwakheka kwamabhamuza nosayizi kuthinta kakhulu indlela umoya-mpilo ohlakazeka ngayo kuyo yonke i-bioreactor. Izici ze-Bubble zithonywa kakhulu usayizi we-pore nokusatshalaliswa, impahla yokusabalalisa, izinga lokugeleza, izakhiwo zoketshezi negesi, kanye nokucindezela. Isibonelo, izifutho ezincane zikhiqiza amabhamuza amancane, ayindilinga, kuyilapho izifutho ezinkudlwana zikhiqiza amabhamuza amakhudlwana futhi angafananga ngendlela efanayo.

Ama-spager amancane akhiqiza amabhamuza anosayizi omncane nayindilinga, futhi ukungezwani kwendawo kungamandla abusayo njengoba edlula ku-bioreactor. Ngakho-ke, banesikhathi eside sokuhlala ku-reactor, okuthuthukisa ukudluliswa kwe-oksijeni, kodwa akufanelekile ukususa i-carbon dioxide esikweni.

Ama-nebulizers amakhulu akhiqiza amabhamuza anobubanzi obuyi-1-4 mm, lapho ukungezwani okungaphezulu kanye nokuqina komhluzi kuhlangana ukuze kuthonye ukuma nokunyakaza kwawo. Lawa mabhamuza anesikhathi esifushane sokuhlala kodwa mancane amathuba okuthi ancibilike kunamabhamuza amancane. Kodwa-ke, ama-spager amancane angase futhi akhiqize amabhamuza ama-asymmetric amakhulu, anamandla angenayo alawula ukuziphatha kwawo. Lawa mabhamuza angaqhuma kalula ngaphandle kokuncibilika noma ukuhlubula i-CO2.

Ukuma nosayizi wamabhamuza kunquma inani lokucindezelwa kwe-shear iseli elizobhekana nalo, ukuphumelela kokukhumula i-CO 2 ohlelweni, kanye nezinga lokudluliswa kwe-oksijini okuphelele kuseli. Ngakho-ke, kubalulekile ukuthuthukisa i-nebulizer ye-bioreactor ukuqinisekisa ukuthi amabhamuza omoya-mpilo afanayo ngosayizi nokusabalalisa futhi awawonakali amaseli.

Isixazululo: Sebenzisa Ukulawulwa Kwekhwalithi Yokukhiqiza Okuqinile kwe-HENGKO Bioreactor Sparger

I-HENGKO ineminyaka engaphezu kwamashumi amabili yesipiliyoni sokuthuthukisa nokukhiqiza i-sparger e-sintered. I-spager yethu yensimbi engagqwali iwumphumela wonjiniyela abaningi abavame ukuthuthukisa indlela yokukhiqiza ukuze bakhiqize lo mkhiqizo wekhwalithi ephezulu onezimbotshana ezifanayo futhi, ngaleyo ndlela, usayizi webhamuza ofanayo okhishwe ku-bioreactor. Ama-spager ethu anezimbotshana anconywa ukuthi asetshenziswe nezilawuli zokugeleza kwe-mass flow low-flow.

Isetshenziswa kanjani:Isilawuli sokugeleza kwesisindo esiphansi sethula kancane kancane umoya-mpilo ku-sparger enezimbotshana. I-spager ayikhiphi igesi ngokushesha. Esikhundleni salokho, ingcindezi iyanda kancane kancane kuze kufike iphuzu elibucayi, lapho ama-bubbles ekhishwa kancane ku-bioreactor.

Kusetshenziswa le ndlela yokuphumula, izinga lokugeleza kwesisindo somoya-mpilo lingalungiswa ukuze kulawulwe izinga lokukhululwa kwamabhamuza ku-bioreactor. Izimbobo ku-sparger zincane ngokwanele ukuthi amabhamuza azokwakheka ngokubikezelwa. Ngakho-ke, lobu buchwepheshe be-bioreactor sparging buyakaleka kubo bonke osayizi bemikhumbi, ngezinga lokudlulisa umoya-mpilo elilingana nezinga lokugeleza kwegesi.

Imibuzo Mayelana ne-Bioreactor Sparger

1. Iyini i-Sparger ku-Bioreactor?

Ngamafuphi, i-sparger iyithuluzi elisetshenziswa ku-bioreactor ukwethula amagesi, afana nomoya-mpilo noma umoya, endaweni yoketshezi. Umsebenzi oyinhloko we-sparger ukuhlinzeka nge-oksijini kuma-microorganisms ku-bioreactor, okudingekayo ekukhuleni kwawo kanye ne-metabolism.

I-Sparger ku-bioreactor isetshenziselwa ukwengeza amagesi afana nomoya-mpilo, umoya, noma amanye amagesi adingekayo ekukhuleni nasekusebenzeni komzimba kwamagciwane. Umoya-mpilo unikezwa amagciwane nge-Sparger, esiza ukugcina amazinga omoya-mpilo ancibilikile endaweni yoketshezi. Amazinga komoya-mpilo ancibilikisiwe ayipharamitha ebalulekile okufanele iqashwe futhi ilawulwe ngesikhathi se-bioprocess njengoba ithinta ngqo ukukhula kanye nokugaywa kwe-metabolism kwama-microorganisms.

I-Sparger iklanyelwe ukwethula igesi endaweni ewuketshezi ngendlela elawulwayo, njengezinto ezinezimbotshana noma amashubhu. I-Sparger ingatholakala ngezansi noma phezulu kwe-bioreactor, kuye ngokuthi i-bioreactor iklanywe kanye nohlobo lwama-microorganisms asetshenzisiwe. I-Sparger ingashintshwa ukuze inikeze izinga lokudluliswa komoyampilo elifiswayo kanye nokugcina izinga elifanele le-oxygen encibilikile phakathi nendawo.

I-Sparger nayo idlala indima ebalulekile ekugcineni izinga lokudluliswa kobuningi, okuyizinga lapho umoya-mpilo udluliselwa khona usuka esigabeni segesi uye esigabeni se-liquid. Izinga lokudlulisa ngobuningi lingathonywa izici ezifana nosayizi nokuma kwe-bioreactor, uhlobo nokugxilisana kwamagciwane, kanye nezinga lokushisa ne-pH yendawo ephakathi. I-Sparger ingasetshenziswa ukulawula lezi zici kanye nokwandisa izinga lokudlulisa ngobuningi, elibalulekile ukuze kuphumelele i-bioprocess.

Kafushane, umsebenzi oyinhloko we-sparger ku-bioreactor ukuhlinzeka nge-oksijini kuma-microorganisms ku-liquid medium, okudingekayo ekukhuleni kwawo kanye ne-metabolism, kanye nokugcina amazinga afanele komoya-mpilo ancibilikisiwe kanye nezinga lokudluliswa kwenqwaba, okubalulekile impumelelo ye-bioprocess.

Usho ukuthini u-Sparger?

I-sparger iyithuluzi elisetshenziselwa ukufaka igesi oketshezini. Ivame ukusetshenziswa kuma-bioreactors, okuyimikhumbi ekhethekile esetshenziselwa ukutshala ama-microorganisms noma amaseli ngaphansi kwezimo ezilawulwayo.

Uyini Umsebenzi weSparger?

Umsebenzi we-sparger ukuhlinzeka nge-oksijini noma enye igesi ku-bioreactor ukuze kusekelwe ukukhula kanye ne-metabolism yamaseli noma ama-microorganisms.

Iyini Ukusetshenziswa kwe-Sparger ku-Bioreactor Chaza Izinhlobo Zayo?

Kunezinhlobo eziningana zama-spager angasetshenziswa ku-bioreactor. Lezi zihlanganisa ama-bubble spagers, adala ukugeleza okuqhubekayo kwamabhamuza oketshezini, kanye nama-spager afutha, ahlakaza igesi njengenkungu enhle. Ezinye izinhlobo zama-spargers zihlanganisa ama-spargers anezimbobo kanye nama-hollow-fiber spagers.

Ikuphi I-Sparger Itholakala e-Bioreactor?

I-sparger ngokuvamile itholakala ngaphansi kwe-bioreactor, lapho ingaxuba kahle igesi noketshezi. Ezinqubweni ezinkulu zokuvutshelwa, ama-bubble spager avame ukusetshenziswa njengoba alula futhi angabizi ukusebenza.

Iluphi Uhlobo LweSparger Olusetshenziswa Kakhulu Ekuvubeleni Okukhulu?

Ezinqubweni ezinkulu zokuvutshelwa, ama-bubble spager avame ukusetshenziswa njengoba alula futhi angabizi ukusebenza. I-bubble sparger iqukethe ishubhu noma ipayipi elinezimbobo ezincane noma izimbobo lapho igesi ingeniswa khona oketshezini. Igesi igeleza emigodini noma ezikhaleni futhi yakhe umfudlana wamabhamuza oqhubekayo oketshezini. Ama-Bubble spagers ayasebenza ekunikezeni umthamo omkhulu wegesi ku-bioreactor futhi angalungiswa kalula ukuze alawule izinga lokugeleza kwegesi. Futhi kulula ukuwahlanza nokuyinakekela. Kodwa-ke, ama-bubble spagers angakha amabhamuza amakhulu ngokuqhathaniswa okungenzeka angasebenzi kahle ekunikezeni indawo ephezulu ukuze amaseli noma ama-microorganisms ahlangane negesi. Kwezinye izimo, i-spray sparger noma olunye uhlobo lwe-sparger lungase lufaneleke kakhulu inqubo ethile yokuvutshelwa.

Yini Okufanele Uyazi NgeSparger System?

Kunezinto ezimbalwa okufanele uzicabangele lapho usebenzisa uhlelo lwe-sparger ku-bioreactor. Lokhu kubandakanya:

1. Ukulinganisa:Kubalulekile ukulinganisa kahle izinga lokugeleza kwegesi elethwa ku-bioreactor. Lokhu kuzoqinisekisa ukuthi inani elilungile legesi linikezwa amaseli noma amagciwane nokuthi ukugcwala komoyampilo ku-bioreactor kungaphakathi kwebanga elifiswayo.

2. Ukugxila komoyampilo:Ukugcwala komoyampilo ku-bioreactor kufanele kuqashelwe njalo ukuze kuqinisekiswe ukuthi kungaphakathi kwebanga elifiswayo lamaseli noma ama-microorganisms atshalwayo. Uma ukugcwala komoyampilo kuphezulu kakhulu noma kuphansi kakhulu, kungathinta ukukhula kanye nemetabolism yamaseli noma ama-microorganisms.

3. Ukuvimbela ukungcola:Kubalulekile ukuqinisekisa ukuthi i-sparger kanye nendawo ezungezile zihlanzwa kahle futhi zigcinwe ukuze kuvinjelwe ukungcoliswa kwe-bioreactor. Lokhu kungase kuhlanganise ukushintsha njalo izihlungi zegesi nokuhlanza i-sparger nezindawo ezizungezile ngezibulala-magciwane ezifanele.

4. Izinga lokugeleza kwegesi:Izinga lokugeleza kwegesi kufanele lilungiswe njengoba kudingeka ukuze kugcinwe ukugcwala komoyampilo ofunekayo ku-bioreactor. Izinga lokugeleza kungase kudingeke ukuthi linyuswe noma lehliswe ngokusekelwe esidingweni komoya-mpilo samaseli noma ama-microorganisms kanye nezinga lokusetshenziswa kwegesi.

5. Ukunakekela:Ukugcinwa njalo kohlelo lwe-sparger kubalulekile ukuze kuqinisekiswe ukuthi lusebenza ngendlela efanele nangempumelelo. Lokhu kungase kuhlanganise ukuhlola ukuvuza, ukushintsha izingxenye ezigugile noma ezilimele, nokuhlanza isipaji nezindawo ezizungezile njengoba kudingeka.

2. Umsebenzi Oyinhloko we-Sparger ku-Bioreactor?

Umsebenzi oyinhloko we-sparger ku-bioreactor ukwethula amagesi, afana nomoya-mpilo noma umoya, endaweni yoketshezi. Kuyadingeka ekukhuleni nasekukhuleni kwe-metabolism yama-microorganisms ku-bioreactor, njengoba adinga umoya-mpilo wokuphefumula. I-Sparger isiza ukuhlinzeka ama-microorganisms umoya-mpilo odingekayo futhi igcine izinga le-oksijini elifanele ku-bioreactor ukuze isekele ukukhula nokugaya umzimba, okubalulekile ekuphumeleleni kwe-bioprocess.

A: Sethula amagesi:Umsebenzi oyinhloko we-sparger ku-bioreactor ukwethula amagesi, afana nomoya-mpilo noma umoya, endaweni yoketshezi. Kuyasiza ukunikeza ama-microorganisms umoya-mpilo odingekayo wokukhula kanye ne-metabolism.

B: Ukugcina amazinga e-oxygen encibilikile:I-Sparger isiza ukugcina amazinga e-oxygen encibilikile endaweni yoketshezi. Lawa mazinga ayipharamitha ebalulekile okufanele iqashwe futhi ilawulwe ngesikhathi se-bioprocess njengoba ithinta ngqo ukukhula kanye ne-metabolism yama-microorganisms.

C: Ukulawula izinga lokudluliswa kwegesi:I-Sparger yakhelwe ukwethula igesi endaweni ewuketshezi ngendlela elawulwayo. I-Sparger ingashintshwa ukuze inikeze izinga lokudluliswa komoyampilo elifiswayo kanye nokugcina izinga elifanele le-oxygen encibilikile phakathi nendawo.

D: Ukugcina izinga lokudluliswa kwenqwaba:I-Sparger nayo idlala indima ebalulekile ekugcineni izinga lokudluliswa kobuningi, okuyizinga lapho umoya-mpilo udluliselwa khona usuka esigabeni segesi uye esigabeni se-liquid.

E: Ukuthuthukisa i-bioprocess:I-Sparger ingasetshenziswa ukulawula izici ezifana nosayizi nokuma kwe-bioreactor, uhlobo, nokugxilisana kwamagciwane, kanye nezinga lokushisa ne-pH yendawo emaphakathi, ukuze kuthuthukiswe i-bioprocess.

F: Ukuhlinzeka Ngokuxuba:Ama-Spargers aphinde asize ekwakheni ingxube ye-homogenous yoketshezi kanye negesi ngokunikeza isenzo sokuxuba. Kuyasiza ekuhlinzekeni ama-microorganisms ngendawo efanayo.

3. Izinhlobo ze-Sparger ku-bioreactor?

Izinhlobo ezimbalwa zama- spargers zifaka ama-sparger amatshe anezimbotshana enziwe ngezinto ezimbotshana ezifana ne-ceramic noma i-sintered metal kanye nama-spager ekholomu yebhamuza, asebenzisa uchungechunge lwamashubhu noma imibhobho ukwethula igesi oketshezini.

Izinhlobo eziningana zama-spager zingasetshenziswa ku-bioreactor, kufaka phakathi:

1. Amatshe anembobo:Lezi zenziwe ngezinto ezimbotshana ezifana ne-ceramic noma i-sintered metal futhi zibekwe ngaphansi kwe-bioreactor. Ahlinzeka ngendawo enkulu yokudlulisa igesi futhi avame ukusetshenziswa kuma-bioreactors amancane.

2. Amakholomu we-Bubble spagers:Lezi zisebenzisa uchungechunge lwamashubhu noma imibhobho ukwethula igesi oketshezini. Angabekwa ngezansi noma ngaphezulu kwe-bioreactor futhi avame ukusetshenziswa kuma-bioreactors anesilinganiso esikhulu.

3. I-ring sparger:Lezi zibekwe ngaphansi kwe-bioreactor futhi zisebenzisa isakhiwo esimise njengendandatho ukukhiqiza amabhamuza nokuhlinzeka ngokudluliswa komoyampilo.

4. I-Micro-bubble Sparger:Lawa aklanyelwe ukukhiqiza amabhamuza amancane ahlinzeka ngokusebenza kahle kokudluliswa komoyampilo futhi asetshenziswa kakhulu kuma-bioreactors amakhulu, aphezulu.

5. I-Jet sparger:Lezi zisebenzisa isethi yemibhobho ukwethula igesi oketshezini. Angabekwa ngezansi noma ngaphezulu kwe-bioreactor futhi avame ukusetshenziswa kuma-bioreactors ashear kakhulu.

6. I-Paddlewheel sparger:Lolu hlobo lwe-Sparger lisebenzisa isondo lokugwedla elizungezayo ukuze lidale amabhamuza futhi linikeze ukudluliswa komoyampilo. Ivame ukusetshenziswa ezinqubweni zokuvutshelwa.

Lezi ezinye zezinhlobo ze-sparger ezivame ukusetshenziswa kuma-bioreactors, futhi ukukhetha kwe-Sparger kuncike kusayizi, uhlobo, kanye nomklamo we-bioreactor kanye ne-bioprocess ethize esetshenziswayo.

4. Ungawasetha Kanjani Amazinga Okungena Ku-Bioreactor?

Izinga le-sparging ku-bioreactor livamise ukusetha ngokususelwe esidingweni se-oxygen yama-microorganisms, izinga lokudluliswa kwegesi, nezinga lokugeleza kwegesi. Izinto ezingase zibe nomthelela ezingeni le-sparging zihlanganisa usayizi nokuma kwe-bioreactor, uhlobo nokugxilisana kwama-microorganisms, kanye nezinga lokushisa ne-pH yendawo ephakathi.

5. Iqhaza lika-Sparger ku-Bioreactor?

Indima ye-sparger ku-bioreactor ukwethula amagesi, afana nomoya-mpilo noma umoya, endaweni ewuketshezi ukuze ihlangabezane nesidingo somoya-mpilo samagciwane. Ibalulekile ekukhuleni nasekukhuleni kwemetabolism yamagciwane futhi, ekugcineni, impumelelo ye-bioprocess.

I-Sparger isiza ukuhlinzeka ama-microorganisms umoya-mpilo odingekayo ekukhuleni nasekusebenzeni komzimba. Kuyasiza ukugcina amazinga e-oksijini ancibilikisiwe endaweni ye-liquid, okuyimingcele ebalulekile yokuqapha nokulawula ngesikhathi se-bioprocess njengoba ithinta ngokuqondile ukukhula kanye ne-metabolism yama-microorganisms.

I-Sparger iklanyelwe ukwethula igesi endaweni ewuketshezi ngendlela elawulwayo, njengezinto ezinezimbotshana noma amashubhu. I-Sparger ingatholakala ngezansi noma phezulu kwe-bioreactor, kuye ngokuthi i-bioreactor iklanywe kanye nohlobo lwama-microorganisms asetshenzisiwe. I-Sparger ingashintshwa ukuze inikeze izinga lokudluliswa komoyampilo elifiswayo kanye nokugcina izinga elifanele le-oxygen encibilikile phakathi nendawo.

I-Sparger nayo idlala indima ebalulekile ekugcineni izinga lokudluliswa kobuningi, okuyizinga lapho umoya-mpilo udluliselwa khona usuka esigabeni segesi uye esigabeni se-liquid. Izinga lokudlulisa ngobuningi lingathonywa izici ezifana nosayizi nokuma kwe-bioreactor, uhlobo nokugxilisana kwamagciwane, kanye nezinga lokushisa ne-pH yendawo ephakathi. I-Sparger ingasetshenziswa ukulawula lezi zici kanye nokwandisa izinga lokudlulisa ngobuningi, elibalulekile ukuze kuphumelele i-bioprocess.

I-Sparger iphinde isize ekwakheni ingxube ye-homogenous yoketshezi kanye negesi ngokunikeza isenzo sokuxuba. Kuyasiza ekuhlinzekeni ama-microorganisms ngendawo efanayo.

Kafushane, indima ye-sparger ku-bioreactor ukuhlinzeka nge-oksijini kuma-microorganisms ku-liquid medium, okudingekayo ekukhuleni kwawo kanye ne-metabolism, kanye nokugcina amazinga omoya-mpilo afanelekile ancibilikisiwe kanye nezinga lokudlulisa ngobuningi, okubalulekile ukuze impumelelo ye-bioprocess. Kuyasiza futhi ukudala ingxube ye-homogenous futhi inikeza isenzo sokuxuba endaweni yoketshezi.

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