I-sparger ye-Bioreactor esetshenziswa kanye yokukhulisa amaseli

Esigabeni sokuqala sokucubungula okuphezulu ekucutshungulweni kwezinto eziphilayo, ukuvutshelwa kuvame ukusetshenziswa. Ukuvutshelwa kuchazwa njengezinguquko zamakhemikhali ezibangelwa ama-microorganism ekukhiqizweni kwemithi neminye imikhiqizo ye-biotechnology. Le nqubo ivame ukwenzeka kuma-bioreactor noma kuma-fermenters, kuye ngokuthi kusetshenziswe yiphi indlela yokukhulisa. Le mikhumbi ye-bioreactor ivumela ukuqapha okuqinile nokulawula ukukhula kwama-microorganism (noma amaseli ezilwane ezincelisayo) kanye nokuhlanganiswa komkhiqizo.

Ukubilisa kuyisisekelo sokukhiqizwa komkhiqizo wokugcina embonini ye-bioprocessing.

I-bioprocessing kanye nezinkampani ezigxile emikhiqizweni yokwelapha esekelwe kumaseli kanye nezakhi zofuzo ziyaqonda ukuthi izimo ezifanele zokwenziwa kwamagciwane kumele zinikezwe ngesikhathi sokusetshenziswa kokubilisa. Ngaphezu kwalokho, inqubo yokubilisa kumele isize ekuqinisekiseni isivuno esisebenziseka kalula ngokwezomnotho, okwenza kube nokukhiqizwa okukhulu okungabizi kakhulu. Izikhungo zesimanje zokucubungula nge-bioprocessing zinebanga lomthamo wamalitha ayi-1,000 kuya kwangu-25,000. Ukukhulisa izinto eziphilayo kusukela kumaseli ayizigidi ezimbalwa kumamililitha ambalwa okukhula kuya kulezi zisivuno zokukhiqiza kuyinselele edinga ukudluliselwa kwesitshalo esingenamagciwane kuzo zonke izindawo zokutshala imbewu.

Ubuchwepheshe obulahlwayo, obaziwa nangokuthi i-Single-Use Technologies (SUT), bungathuthukisa kakhulu ukusebenza kahle kokubilisa.

Uhlobo oluthuthukisiwe lwe-SUT luvumela onjiniyela be-bioprocess ukuthi bakhethe izinhlelo ezilahlwayo kanye namapayipi okulethwa ukuze bathathe indawo yemikhumbi yokugcina kanye namanethiwekhi epayipi aqinile. Njengoba ukuthandwa kwe-SUT kukhula, abakhiqizi be-bioprocessing bangaklama izinhlelo zokulima imbewu eziguquguqukayo eziqukethe ama-bioreactors (ama-SUB) asetshenziswa kanye kuphela anezinhlobo ezahlukene noma basebenzise inhlanganisela yama-SUB kanye nama-reactors ensimbi engagqwali yendabuko ukuze kufezwe umkhiqizo omkhulu kakhulu. Ukusetshenziswa kwama-coupling aseptic e-CPC noma ama-coupling emishini yokuhlanzeka, afakwe izixhumi ze-in situ steam-in-place (SIP), kuvumela ukudluliselwa okulula nokuphephile kwe-culture medium ngesikhathi sokuxhuma izingxenye ezahlukene.

Amatshe omoya alahlwayo angenawo amagciwane e-bioreactor aklanyelwe inqubo yokubilisa i-bioreactor

Umkhiqizi we-HENGKO usebenzisa uhla olubanzi lwezingxenye zesihlungi sensimbi engagqwali esilahlwayo ukuze adale izinqubo zokubilisa kanye nokukhiqiza amakhasimende ethu azilindele. I-Hengge inikeza uhla olubanzi kakhulu lwezixazululo zokuxhumeka ezisetshenziswa kanye, ihlanganisa ngokuthembekile lobu buchwepheshe ngenkathi igcina ukuqina kanye nobuqotho bohlelo lonke.

Ukuguquguquka Nokuguquguquka
Amatshe omoya ahlanzekile kaHENGER ayaguquguquka ngoba ukwakhiwa komkhiqizo kanye nokubukeka kwawo kanye nezingxenye zokuxhuma zingaklanywa futhi zenziwe ngokwezifiso ukuze kuhlangatshezwane nezidingo zamakhasimende.

Umklamo Omusha
Ithimba lethu lonjiniyela bokuklama kanye nohlelo lokusebenza lwe-bioprocessing ligxile ekwakheni imikhiqizo emisha, esezingeni eliphezulu eyenza ukudlulisa imithombo engcolile kube lula futhi kuphephe. ​​Njengoba umphumela wokubilisa we-reactor uhluka kuye ngokuthi ukhetha ini, amatshe omoya angcolile e-hengko atholakala ngobukhulu obuhlukahlukene, ukucushwa, izinketho zokugcina kanye nezinto zokwakha futhi enziwe ngezinto zokusetshenziswa ezisezingeni eliphezulu. Imikhiqizo emisha iqinisekisa ukusetshenziswa okulula kanye nokuqinisekiswa kokuxhumeka. Ukuthembeka ongakwethemba

Ukwethembeka ongakwethemba
Amatshe Omoya akhelwe zonke izinhlelo zokusebenza ze-bioprocessing kuma-bioreactor. Ngokusiza ukugcina ukudluliselwa kwemidiya okuhlanzekile, amatshe omoya asiza ekutholeni isivuno esihle ngentengo engabizi kakhulu. Zonke izixazululo zamatshe omoya zihlolwa ngokucophelela (kufaka phakathi ukuhlolwa kwezinto, ukuhlolwa komkhiqizo kanye nokuhlolwa kokuqina komkhiqizo) ukuze kuhlangatshezwane nemininingwane yomkhiqizo. Eqinisweni, i-hengko inikeza ukusebenza okuthembekile, okuphindaphindwayo ngokuqinisekiswa kwezakhiwo ezisekelayo kanye nemibiko ekhishwayo.

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isiko lamaseli
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